The San Francisco 49ers and Los Angeles Rams have aspirations of winning the NFC West and making another Super Bowl run, but both are dealing with significant losses on offense entering Week 3 when they go head-to-head.

Week 3 features some key games between 2-0 teams, including the Texans at the Vikings and the Chargers at the Steelers. And one of the best matchups will be America’s Game of the Week: the somehow winless Ravens visiting the inconsistent Cowboys.

This will be a week of Davids facing Goliaths as far as betting is concerned: Seven of the 16 matchups opened with the favorite giving up at least 6.5 points to the underdog. Fire